Zyban, a new anti-smoking treatment, may interact with anti-HIV therapies. Zyban, also know as bupropion, has not been thoroughly investigated in people taking antiretrovirals as yet, but its common metabolism though the P450 enzyme system in the liver means that interactions with certain drugs are likely. People taking Zyban with anti-HIV therapy should discuss the potential for interactions with their doctor or pharmacist.
The drug is contraindicated with ritonavir, and according to drug interaction experts at the University of Liverpool, its use should be closely monitored when it is taken alongside other protease inhibitors, or NNRTIs, as a change in dosage (most likely of Zyban) may be required.
Zyban is not nicotine-based and differs from other options currently available for those who want to quit smoking. Bupropion is an antidepressant marketed by Glaxo Wellcome as Wellbutrin. Zyban is also produced by Glaxo Wellcome.