Saunas and drugs linked with rectal gonorrhoea in gay men in San Francisco study

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For HIV-positive gay men in San Francisco, having anonymous sex in a sauna is associated with an increased risk of rectal gonorrhoea, according to a study published in the November 2003 edition of Sexually Transmitted Diseases. The study also found that rectal gonorrhoea in HIV-negative men was associated with the use of recreational drugs, particularly stimulants in the amphetamine class. Earlier published research from the same investigators found that the recent resurgence of syphilis amongst gay men in San Francisco was associated with meeting sexual partners on-line (see link below).

For six months in 2000 doctors at a sexual health clinic in San Francisco screened all men reporting receptive anal sex for gonorrhoea, irrespective of reported condom usage. A total of 564 men were included in the study, which also involved self-completion of a questionnaire to provide demographic details, information on recent sexual encounters, drug use, and HIV status.

Of all the men in the study, a little over 7% tested positive for rectal gonorrhoea. However, the percentage of HIV-positive men with the sexually transmitted infection was over twice as high at 15.2%, a highly significant difference (p<0.01).

Glossary

rectum

The last part of the large intestine just above the anus.

p-value

The result of a statistical test which tells us whether the results of a study are likely to be due to chance and would not be confirmed if the study was repeated. All p-values are between 0 and 1; the most reliable studies have p-values very close to 0. A p-value of 0.001 means that there is a 1 in 1000 probability that the results are due to chance and do not reflect a real difference. A p-value of 0.05 means there is a 1 in 20 probability that the results are due to chance. When a p-value is 0.05 or below, the result is considered to be ‘statistically significant’. Confidence intervals give similar information to p-values but are easier to interpret. 

receptive

Receptive anal intercourse refers to the act of being penetrated during anal intercourse. The receptive partner is the ‘bottom’.

multivariate analysis

An extension of multivariable analysis that is used to model two or more outcomes at the same time.

syphilis

A sexually transmitted infection caused by the bacterium Treponema pallidum. Transmission can occur by direct contact with a syphilis sore during vaginal, anal, or oral sex. Sores may be found around the penis, vagina, or anus, or in the rectum, on the lips, or in the mouth, but syphilis is often asymptomatic. It can spread from an infected mother to her unborn baby.

The men in the study had a median age of 33 years, were well educated, with 78% having a college degree, and almost two thirds (65%) were white. There were no demographic differences between the men with and without rectal gonorrhoea.

Symptoms were present in only 10.5% of cases of rectal gonorrhoea.

HIV-positive men reporting anonymous receptive anal sex in the past fortnight had a two-fold higher risk of rectal infection with gonorrhoea than positive men reporting no anonymous receptive anal sex, however this difference was not statistically significant (p=0.1). However, a significantly increased risk of gonorrhoea was found for HIV-infected men who met their partners at either saunas or over the internet (p=0.06 and p=0.04 respectively).

For HIV-negative men, or men of unknown HIV status, the investigators found a significant relationship between rectal gonorrhoea and the use of amphetamines (p=0.02) and poppers (p=0.08) during sex.

In multivariate analysis, meeting an anonymous partner at a sauna in the previous two weeks remained significantly associated with rectal gonorrhoea for HIV-positive men (OR, 3.39, 95% CI, 0.80 – 14.44, p<0.1). Sex whilst “high” on drugs remained significantly associated with a rectal gonorrhoea infection for HIV-negative or untested men (OR, 2.94; 95% CI, 1.03 – 8.34, p<0.05), as did, unsurprisingly, unprotected receptive anal sex (OR, 4.06; 95% CI, 1.31 – 12.53, p<0.05).

The investigators describe the prevalence of rectal gonorrhoea in their study as “high.” As infection with HIV and gonorrhoea have a “strong biological association”, the investigators suggest that the recent increase in new HIV infections in San Francisco could have been fuelled by rectal gonorrhoea.

In conclusion the investigators emphasise the need for doctors and clinics to promote regular sexual health check-ups and the integration of HIV and sexually transmitted infection efforts.

Further information on this website

Gonorrhoea is STI most likely to cause HIV rebound in semen of HAART patients - news story

Gonorrhoea - factsheet

Gonorrhoea treatment guidelines need urgent review, say public health officials - news story

Internet the most commonly used venue to cruise for sex by gay men with syphilis in SF - news story

Rate of unprotected sex between men of unknown HIV status increased from 1999 - '01 in San Francisco - news story

References

Kim AA et al. Risk factors for rectal gonoccal infection amidst resurgence in HIV transmission. Sexually Transmitted Diseases 30: 813 – 817, 2003.