IAS: Maraviroc produces best results when combined with another active drug

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Adding another potent antiretroviral to the new CCR5 antagonist maraviroc (Celsentri) in treatment-experienced patients gives added benefit, according to a new analysis of the MOTIVATE study data presented as a poster to the recent International AIDS Society Conference in Sydney.

The MOTIVATE 1 and 2 studies were conducted in heavily treatment-experienced HIV-infected individuals with CCR5-tropic virus. Patients in the studies had taken several antiretroviral regimens and developed significant drug resistance. The trials were sufficiently similar in design to allow the results to be combined.

Patients were given maraviroc or placebo plus optimised background therapy (OBT) but for some patients that OBT contained at least one potent antiretroviral that the patient had never used before. These were enfuvirtide (Fuzeon), lopinavir/ritonavir (Kaletra), tipranavir (Aptivus), fosamprenavir (Telzir) or atazanavir (Reyataz).

Glossary

treatment-experienced

A person who has previously taken treatment for a condition. Treatment-experienced people may have taken several different regimens before and may have a strain of HIV that is resistant to multiple drug classes.

CCR5

A protein on the surface of certain immune system cells, including CD4 cells. CCR5 can act as a co-receptor (a second receptor binding site) for HIV when the virus enters a host cell. A CCR5 inhibitor is an antiretroviral medication that blocks the CCR5 co-receptor and prevents HIV from entering the cell.

placebo

A pill or liquid which looks and tastes exactly like a real drug, but contains no active substance.

drug resistance

A drug-resistant HIV strain is one which is less susceptible to the effects of one or more anti-HIV drugs because of an accumulation of HIV mutations in its genotype. Resistance can be the result of a poor adherence to treatment or of transmission of an already resistant virus.

optimised background therapy

When a new drug is added to a failing HIV regimen, the other drugs in the regimen (the 'background therapy') may also be changed. Any changes are based on a person’s resistance test results and treatment history. Optimised background therapy gives a new HIV regimen (or an experimental HIV drug being studied in a clinical trial) the best chance of succeeding. 

Darunavir (Prezista) was not included in the trial as it was only available under expanded access at the time of the study and no information on drug interactions was available.

The investigators used the GSS (Genotypic Susceptibility Score) to indicate the total number of drugs in the OBT to which the patient's virus was susceptible.

Patients taking maraviroc plus another potent drug they had not used before were significantly more likely to achieve viral loads of less than 50 copies/ml.

For example, 53% of patients taking maraviroc 300mg twice a day plus enfuvirtide for the first time achieved viral loads of less than 50 copies/ml compared to just 33% of enfuvirtide resistant or experienced patients taking maraviroc.

The results are consistent with results from a GSS analysis which showed that patients with more potentially active drugs in their OBT were more likely to achieve virologic suppression on maraviroc. Fifty-five per cent of patients with two active drugs acheived viral load below 50 copies/ml at week 24, compared with 32% of patients with no active drugs in the OBT.

The authors say the data demonstrate the added treatment benefit of including another potent new drug as part of an OBR when initiating maraviroc in patients who are known to have significant resistance.

Maraviroc recently received accelerated approval for use by treatment experienced patients in the US. Formal approval in Europe is expected in the autumn.

References

van der Ryst E et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-week combined analysis of the MOTIVATE 1 and 2 studies. 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, abstract WEPEB115LB, Sydney, 2007.