We take medicines to make us better or to keep us well, but all medicines can cause unwanted effects. These are usually called side-effects, but you may also hear them referred to as ‘secondary effects’, 'adverse effects' or 'adverse drug reactions'.
Side-effects can be experienced by anyone taking anti-HIV drugs – including people who have an undetectable viral load and high CD4 cell count and who don’t have any symptoms of HIV infection. But that doesn’t mean that everyone who takes anti-HIV drugs will definitely have side-effects – many people don’t experience any at all.
The drugs that are now recommended for people starting HIV treatment for the first time generally have few side-effects. However, any possible side-effects should be taken into consideration when choosing your treatment combination and your doctor will discuss these with you. Your doctor will also be able to suggest treatments to minimise the impact of side-effects if you do experience them.
The most common side-effects are the result of your body getting used to a new drug and, after a few weeks, these side-effects usually lessen or go away completely.
Some common short-term side-effects of anti-HIV drugs are:
Mood and sleep problems, sexual problems and rash are also possible side-effects of some anti-HIV drugs. (See below for information on rash as an allergic reaction.)
If you inject your HIV medicine, you might find the area where it’s injected (usually your bottom or thigh muscles) gets sore. This usually gets better after a few days.
Talk to your doctor about any side-effects you are experiencing for advice on how they can be managed. Your doctor may suggest other medicines to control some of these side-effects such as anti-diarrhoea medication, anti-sickness medication (called anti-emetics), or painkillers.
Some anti-HIV drugs have a risk of causing a hypersensitivity (allergic) reaction. The drugs with the greatest risk of hypersensitivity are abacavir and nevirapine.
Abacavir (Ziagen, Kivexa, Triumeq) can cause a serious allergic reaction in some people. Before starting this drug, you will have a genetic test to see if you have a particular gene that is associated with having this reaction. If the test is positive, you must not take abacavir.
Nevirapine (Viramune) can cause a serious allergic reaction in some people; this is more likely in the first 18 weeks of treatment.
Some people have also had a very rare allergic reaction to the following drugs:
An allergic reaction can be very dangerous. If you are about to start one of these drugs, it is a good idea to talk to your doctor about the possible signs of an allergic reaction. A rash together with a fever can be a sign of a reaction.
You should contact your doctor (or A&E if it’s out of hours) immediately if you experience any symptoms suggesting that you might be having an allergic reaction to a drug.
The act of taking a treatment exactly as prescribed. This involves not missing doses, taking doses at the right time, taking the correct amount, and following any instructions about food.
To eliminate a disease or a condition in an individual, or to fully restore health. A cure for HIV infection is one of the ultimate long-term goals of research today. It refers to a strategy or strategies that would eliminate HIV from a person’s body, or permanently control the virus and render it unable to cause disease. A ‘sterilising’ cure would completely eliminate the virus. A ‘functional’ cure would suppress HIV viral load, keeping it below the level of detection without the use of ART. The virus would not be eliminated from the body but would be effectively controlled and prevented from causing any illness.
Human immunodeficiency virus, the virus which causes AIDS. There are two variants: HIV-1, and HIV-2. HIV-1 is by far the most common worldwide. See ‘subtype’ for more information.
Abbreviation of a Latin term meaning every night.
A drug-resistant HIV strain is one which is less susceptible to the effects of one or more anti-HIV drugs because of an accumulation of HIV mutations in its genotype. Resistance can be the result of a poor adherence to treatment or of transmission of an already resistant virus.
If you do experience side-effects of anti-HIV drugs, it is good to know that something can nearly always be done about them. There are also some things you can do to reduce the risk of side-effects or make them less severe if you do experience them.
There can be a daily pattern to side-effects, linked to the time you take your medicines and also to the processing of the drug by your body. It might be possible to minimise the inconvenience that this causes by adjusting the time at which you take your medicines. For example, efavirenz (Sustiva, also in the combination pill Atripla) can cause dizziness and other psychological side-effects. Many people overcome these by taking their daily dose of the drug just before going to bed.
The benefits of taking HIV treatment far outweigh the risks, but some HIV treatment has been linked to an increased risk of longer-term side-effects developing. These include bone, liver and kidney problems, heart disease and metabolic changes. Longer-term side-effects are less common than short-term side-effects.
After starting HIV treatment you’ll have regular blood tests to see if you’re at risk of developing any serious side-effects, and you should mention any unusual symptoms to your doctor. These tests can identify small changes in how your body is working, so that you and your doctor can decide to make changes to your treatment, or take other action, before any serious problems develop.
Some older anti-HIV drugs, which are now avoided as much as possible, can cause the long-term side-effects lipodystrophy, peripheral neuropathy, and lactic acidosis, a very rare but serious condition.
Most people gain some weight after starting antiretroviral treatment. However, some people gain a lot of weight when they start or switch HIV treatment. It’s not known for sure why this happens, but it’s more likely if one or more of the following is true:
If you’ve gained weight and you’re worried about it, speak to your doctor. There is more information about weight gain and HIV treatment on this page.
Your doctor can usually do something about side-effects, so it makes good sense to mention any that you’re experiencing. If side-effects do persist, changing treatment may be an option. All anti-HIV drugs can cause side-effects, so it is possible that the drug you switch to might involve a risk of side-effects as well.
If your viral load is undetectable and you have no resistance to anti-HIV drugs then you should be able to switch to a different treatment. But don’t stop taking your anti-HIV drugs without talking to your doctor.
