Treatment as prevention works!

This article originally appeared in HIV & AIDS treatment in practice, an email newsletter for healthcare workers and community-based organisations in resource-limited settings published by NAM between 2003 and 2014.
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UNAIDS says finding is 'serious game changer' for HIV prevention

A large randomised study of treatment as prevention has closed more than three years early after interim analysis of the data showed that antiretroviral treatment reduced the risk of HIV transmission from treated partner to uninfected partner by 96%.

The magnitude of the reduction in risk is almost the same as that observed in multiple cohort studies in sub-Saharan Africa, and is the strongest effect seen in any trial that has used an antiretroviral-based prevention method.

HPTN 052 is a large, international study which randomised 1736 male-female couples in which one partner was HIV-positive either to begin antiretroviral therapy immediately, or to wait until treatment was clinically indicated (at a CD4 count of 250 cells/mm3).

The study began enrolling participants in 2005 in Botswana, Brazil, India, Kenya, Malawi, South Africa and Zimbabwe, and recruited couples in which the HIV-positive partner had a CD4 cell count between 350 and 550 cells/mm3. The median CD4 count at the time of joining the study was 436 cells/mm3. This level is higher than the threshold at which World Health Organization guidelines currently recommend starting treatment.

Glossary

treatment as prevention (TasP)

A public health strategy involving the prompt provision of antiretroviral treatment in people with HIV in order to reduce their risk of transmitting the virus to others through sex.

statistical significance

Statistical tests are used to judge whether the results of a study could be due to chance and would not be confirmed if the study was repeated. If result is probably not due to chance, the results are ‘statistically significant’. 

transgender

An umbrella term for people whose gender identity and/or gender expression differs from the sex they were assigned at birth.

microbicide

A product (such as a gel or cream) that is being tested in HIV prevention research. It could be applied topically to genital surfaces to prevent or reduce the transmission of HIV during sexual intercourse. Microbicides might also take other forms, including films, suppositories, and slow-releasing sponges or vaginal rings.

safer sex

Sex in which the risk of HIV transmission is reduced or is minimal. Describing this as ‘safer’ rather than ‘safe’ sex reflects the fact that some safer sex practices do not completely eliminate transmission risks. In the past, ‘safer sex’ primarily referred to the use of condoms during penetrative sex, as well as being sexual in non-penetrative ways. Modern definitions should also include the use of PrEP and the HIV-positive partner having an undetectable viral load. However, some people do continue to use the term as a synonym for condom use.

The study was due to run until 2015.

The study was halted after an interim review by the Data and Safety Monitoring Board, which found that 39 infections had occurred. Twenty-eight could be genetically linked to the HIV-positive partner, and of these 27 occurred in couples where the HIV-positive partner did not begin antiretroviral therapy immediately. This translates into a 96% reduction in the risk of transmission. This result was highly statistically significant (P<0.0001).

All participants received regular counselling on safer sex, free condoms and treatment for sexually transmitted infections.

The results of HPTN 052 show that treatment of people with relatively high CD4 cell counts results in very substantial reduction in the risk of HIV transmission.

The study also found a statistically significant reduction in the risk of extrapulmonary tuberculosis in the early treatment arm: 17 cases occurred in the deferred treatment arm, compared to 3 cases in the early treatment arm (p=0.0013).

There was not a significant difference in the death rate, however: 13 deaths occurred in the deferred treatment arm and ten in the immediate treatment arm. There were 105 morbidity and mortality events: 65 events in the delayed treatment arm and 40 in the immediate treatment arm.

Reactions

Coming just ahead of the UN General Assembly Special Session on AIDS early next month in New York, these results are likely to give a powerful boost to messages that greater investment in HIV treatment could have a significant impact on the growth of the epidemic

“This breakthrough is a serious game changer and will drive the prevention revolution forward. It makes HIV treatment a new priority prevention option,” said Michel Sidibé, Executive Director of the Joint United Nations Programme on HIV/AIDS (UNAIDS). “Now we need to make sure that couples have the option to choose Treatment for Prevention and have access to it.”

“People living with HIV can now, with dignity and confidence, take additional steps to protect their loved ones from HIV,” said Mr Sidibé.

 “The upcoming UN High Level Meeting on AIDS should set treatment and prevention targets that take the HPTN 052 results into account,” said Mitchell Warren of AVAC, an organisation which advocates for new HIV prevention technologies. “We need to start critical discussions and come to quick decisions about where and how to deploy treatment as prevention in the short-term. Government and international normative agencies now have a critical mass of data to publish guidelines for appropriate implementation of treatment as prevention in concert with other prevention methods.”

“Today's result should be viewed in light of other recent findings from trials using ARVs for prevention,” said Mitchell Warren. “The recent results from the iPrEx trial showed that PrEP is effective in gay men and transgender women, while the CAPRISA 004 microbicide trial showed that 1% tenofovir gel is effective at reducing HIV risk for women.”

 “Together, these results allow us to imagine a world in which men and women seek HIV testing with the knowledge and confidence that they will receive a range of highly effective options for staying healthy and protecting themselves and their partners—whatever the test result," Warren added.  “The results of the study require us to rethink how we structure the delivery and funding of HIV services overall.“