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Raltegravir may cause temporary worsening of pre-existing depression

Etravirine (Intelence) approved in Europe for treatment-experienced patients

Next generation first-line NNRTI, rilpivirine (TMC278) potent; lowest dose better-tolerated than efavirenz at 96 weeks

Heat-stable ritonavir tablet equivalent to soft gel capsule; may be approved next year

Two new NNRTIs look promising in early clinical trials

Two novel immune therapies in early investigation: autologous dendritic cells and CD4 zeta gene-modified T cells

Slowing CD4 cell decline with IL-2 allows HIV treatment to be deferred by 92 weeks

Raltegravir versus efavirenz in treatment-naïves at 96 weeks: continued efficacy and fewer adverse effects

Gilead now testing ritonavir replacement in human studies