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Second company halts CCR5 inhibitor study in another blow to new drug class

New boosted PIs should be used with T-20 for maximum impact, say new US guidelines

Treatment interruption delivers no benefit for most heavily treated, despite resistance loss

Discordant CD4 increase of 25 cells/mm3 confers clinical benefit despite advanced disease

GSK halts chemokine inhibitor trial due to safety fears

IAS: Needle-free T-20 delivery reduces, but does not eliminate, injection site reactions (corrected)

IAS: Tipranavir combined with T-20 achieves good virologic results in the highly treatment experienced

IAS: Remaining on 3TC despite resistance leads to better immunological and clinical outcomes

Pfizer discontinues capravirine development