Dolutegravir recommended for all in new World Health Organization guidelines

Everyone who starts HIV treatment in lower- and middle-income countries should start treatment with a combination containing dolutegravir, the World Health Organization (WHO) announced at the 10th International AIDS Society Conference on HIV Science (IAS 2019) in Mexico City today.

The new recommendations are intended to settle uncertainty over whether women of childbearing age should take dolutegravir. Last year, WHO issued interim recommendations for dolutegravir use after the Tsepamo surveillance study in Botswana revealed a higher rate of neural tube defects in the infants of women who had been taking dolutegravir around the time of conception. Those recommendations advised that women of childbearing age could receive dolutegravir – if they had access to consistent and reliable contraception – and highlighted the uncertain evidence regarding the safety of dolutegravir.

The new recommendations from WHO are unambiguous. Dolutegravir-based antiretroviral therapy (ART) is recommended as the preferred first-line regimen for all adults and adolescents with HIV. This is classified as a ‘strong’ recommendation by WHO, meaning that if countries ignore it, they are going against compelling evidence that dolutegravir-based ART is now the best-available first-line regimen.

In the updated 2019 guidelines, WHO recommends:

  • Dolutegravir in combination with two nucleoside reverse transcriptase inhibitors (NRTIs) for first-line treatment of all adults and adolescents.
  • Efavirenz 400mg plus two NRTIs as an alternative first-line regimen for adults and adolescents.

Whereas WHO previously recommended efavirenz 600mg, it now supports the lower dose of 400mg which has benefits in terms of side-effects and cost.

The guidelines also make two ‘conditional’ recommendations – meaning the evidence is less certain – for treatment of children and infants:

  • Weight-based dosing of dolutegravir for children and infants where a dose is approved for the age-band.
  • Raltegravir-based ART as an alternative for children and infants where dolutegravir is not available.

The guidelines also recommend that anyone on a failing first-line regimen that does not contain dolutegravir should switch to a second-line regimen of dolutegravir plus a new NRTI backbone.

The new recommendations stress the importance of switching to dolutegravir in settings where resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is rising. Dr Silvia Bertagnolio told a symposium organised by WHO that resistance to NNRTIs is present in over 15% of people starting antiretroviral treatment in Uganda, 20% in South Africa and over 25% in Honduras. Use of efavirenz in these settings is likely to result in treatment failure and further transmission of drug-resistant virus.

Implementing the recommendations is an urgent priority for countries as they work towards achieving the UNAIDS 90-90-90 targets – 90% of people living with HIV knowing their status, 90% of those diagnosed being on antiretroviral therapy and 90% of those on treatment having viral suppression by 2020. Dolutegravir-based treatment has the potential to be cost-saving, better tolerated – leading to better retention in care – and more potent, meaning that fewer people will need to switch to more costly second-line regimens.

The President’s Emergency Plan for AIDS Relief (PEPFAR) has been pushing hard to promote a transition to dolutegravir in all the countries where it funds treatment. However, the concerns over dolutegravir safety led many countries to halt dolutegravir introduction until they had more data.

PEPFAR’s planning for the transition to dolutegravir projected that by this point in 2019, 80-90% of patients would have transitioned to dolutegravir or started treatment on a dolutegravir-containing regimen. In practice, countries are falling far short of these targets as a result of last year’s decisions to restrict women’s access to dolutegravir.

A total of 123 countries have now introduced dolutegravir into first-line recommendations, including 41 lower- and middle-income countries that have adopted dolutegravir, tenofovir and lamivudine as the preferred first-line regimen. All high-burden countries in sub-Saharan Africa have adopted dolutegravir-based ART as the preferred first-line regimen but progress towards dolutegravir adoption is slower in Asia. China, India, Indonesia and Thailand continue to stick with efavirenz-based first-line treatment.

Ambassador Deborah L Birx, US Global AIDS Coordinator and US Special Representative for Global Health Diplomacy, criticised the way in which concerns over dolutegravir safety had resulted in denial of dolutegravir treatment to women in numerous countries.

“If we move policies forward with the speed we shut down access to dolutegravir for women”, the epidemic would be over, Birx told the WHO symposium. “It was shocking.”

“We were saying we have a client-centred approach, but we did not when it came to dolutegravir, so let this be a reminder of where we need to be in the future.”

Jacque Wambui of AfroCAB, an activist living with HIV, said that women need to be allowed an informed choice by health systems. “It is my body, my pregnancy, I am the one who is going to bear the child for nine months. Let the woman know what the risks are, and let the woman decide for herself.”

Rebecca Zash, the Harvard Medical School researcher who led the Tsepamo study said: “Antiretroviral safety data don’t just affect pregnant women, they affect all women on ART.”